Wnting out ocular neovascularization: using nanoparticle delivery of very-low density lipoprotein receptor extracellular domain as Wnt pathway inhibitor in the retina.
نویسندگان
چکیده
منابع مشابه
Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.
OBJECTIVE The deficiency of very low-density lipoprotein receptor resulted in Wnt signaling activation and neovascularization in the retina. The present study sought to determine whether the very low-density lipoprotein receptor extracellular domain (VLN) is responsible for the inhibition of Wnt signaling in ocular tissues. APPROACH AND RESULTS A plasmid expressing the soluble VLN was encapsu...
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عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 35 5 شماره
صفحات -
تاریخ انتشار 2015